Gynaecology Research Today is a free monthly online journal that collates and summarizes the latest research about Gynaecology, including details on pap smears, laparoscopy, ultrasound, hysteroscopy. | ||||||||
|
Estro-progestin supplementation enhances the growth hormone secretory responsiveness to ghrelin infusion in postmenopausal women.Villa P, Costantini B, Perri C, Suriano R, Ricciardi L, Lanzone A Department of Obstetrics and Gynaecology, Catholic University of Sacred Heart, Rome, Italy. paolavilla@rm.unicatt.it OBJECTIVE: To assess the effects of estro-progestin supplementation on ghrelin-mediated GH release, we studied the consequence of ghrelin or saline injection before and after 60 days of hormone therapy or placebo administration in postmenopausal subjects. DESIGN: A prospective double blind, placebo-controlled, and parallel cohort study. SETTING: Catholic University of Sacred Heart, Operative Division of Endocrinological Gynecology. PATIENT(S): Eighteen postmenopausal women participated in the study. INTERVENTION(S): Ten women were randomized to receive estro-progestin treatment (2 mg of hemihydrate E(2) and 10 mg of dydrogesterone in a continuous sequential regimen); eight women were treated with placebo. All patients underwent in a randomized order a ghrelin test (1 microg/kg IV bolus) or a saline infusion (2-mL IV bolus) on two different days, before and after 60 days of treatment. MAIN OUTCOME MEASURE(S): Basal hormonal assays, including ghrelin basal levels. The GH levels were measured at baseline and after 15, 30, 60, 90 minutes of ghrelin or saline injection. RESULT(S): The acute ghrelin injection released a notable GH secretion in all postmenopausal women. After estro-progestin therapy the ghrelin-stimulated GH response was significantly higher than before treatment. In particular, the percent increase of ghrelin GH-releasing effect, expressed as incremental area under the curve (AUCi-GH) was more than 50% after hormone therapy. CONCLUSION(S): In postmenopausal women estro-progestin treatment clearly influenced the ghrelin-stimulated GH secretion. Published 15 February 2008 in Fertil Steril, 89(2): 398-403.
© 2005-2008 Gynaecology Research Today. All Rights Reserved. |
| ||||||
