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Ligneous inflammation involving the female genital tract.

Karaer A, Mert I, Akinsu F, Tug M, Tefs K, Schuster V, Mollamahmutoglu L

Department of Obstetrics and Gynecology, Dr Zekai Tahir Burak Women's Health Education and Reserach Hospital, Ankara, Turkey.

Ligneous inflammation is a rare disease characterized by progressive growth of ligneous plaques on mucosal surfaces. Involvement of the female genital tract is an unusual condition. We present a patient with multifocal ligneous inflammation involving her genital tract, oral mucosa and conjunctiva. Plasminogen functional activity was 18% of normal (reference: 55-145%). Molecular analysis exhibited that her genetic status is homozygous for a combination of three polymorphisms. But no true mutation could be found in all 19 exons of the plasminogen gene. We did not observe any clinical changes, although plasminogen activity has improved in the course of 5 months of oral contraceptive therapy Most gynecologists are unfamiliar with this diagnosis and pathologists with wide experience in gynecology are unaware of this disease. However, the histology of lesions is characteristic and a diagnosis can be made quite easily once it has been considered.

Published 10 August 2007 in J Obstet Gynaecol Res, 33(4): 581-4.
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