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Sperm chromosome analysis in two cases of paracentric inversion.

Vialard F, Delanete A, Clement P, Simon-Bouy B, Aubriot FX, Selva J

Departments of reproductive biology, cytogenetics, gynaecology and obstetrics, CHIPS, Poissy, France; INSERM U407, Oullins, France. fvialard@hotmail.com <fvialard@hotmail.com>

OBJECTIVE: To examine sperm meiotic segregation in men with paracentric inversions. DESIGN: Cases reports, literature review. SETTING: Departments of reproductive biology, cytogenetics, gynaecology, and obstetrics. PATIENT(S): Two patients referred for infertility, heterozygous for a paracentric inversion. INTERVENTION(S): Fluorescence in situ hybridization (FISH) with specific probes and X/Y/18 centromeric probes on 1,000 spermatozoa for the 2 patients and 10 controls. MAIN OUTCOME MEASURE(S): Sperm aneuploidy frequency. RESULT(S): The FISH analysis using the specific probes for the paracentric inversion indicated low disequilibrium (0.4% and 0.5%). The FISH analysis using X/Y/18 centromeric probes indicated aneuploidy frequencies (0.3% and 1.1%), identical to those of control patients with the same sperm parameters. CONCLUSION(S): Paracentric inversion seems to be associated with a very low risk of aneuploidy. A larger study is necessary to explore all chromosome inversions.

Published 5 February 2007 in Fertil Steril, 87(2): 418.e1-5.
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