Gynaecology Research Today is a free monthly online journal that collates and summarizes the latest research about Gynaecology, including details on pap smears, laparoscopy, ultrasound, hysteroscopy. | ||||||||
|
Effect of the oxytocin antagonist antocin and agonist decomoton on baboon luteal cell production and release of progesterone.Dawood MY, Khan-Dawood FS Departments of Obstetrics and Gynecology, West Virginia University School of Medicine, Morgantown, West Virginia; Pathology, West Virginia University School of Medicine, Morgantown, West Virginia. OBJECTIVE: To evaluate the effect of oxytocin, its antagonist antocin, and agonist decomoton on baboon luteal cell P secretion. DESIGN: Prospective study. SETTING: Academic department of obstetrics and gynecology in a US medical school. ANIMAL(S): Luteal-phased timed corpora lutea (CL) from a cohort of adult cycling baboons (Papio anubis). INTERVENTION(S): Dispersed luteal cells from luteal phase baboon CL were cultured and treated with nothing (control), oxytocin (4-400 mU), antocin (4-400 mug), oxytocin with antocin, decomoton (4-400 mug), or oxytocin with decomoton. MAIN OUTCOME MEASURE(S): Basal and hCG (10 U)-stimulated P were measured in the incubate. RESULT(S): Basal P secretion did not change significantly with all peptides studied. The hCG-stimulated P secretion was significantly inhibited by oxytocin (4-400 mU), antocin (4-400 mug), and antocin combined with oxytocin, and with oxytocin, decomoton, and decomoton combined with oxytocin. Antocin (-12%) was less inhibitory than oxytocin (-25% to -22%). Antocin combined with oxytocin enhanced the inhibition to -35% to -39%. Decomoton had stronger (not significant) inhibition than oxytocin. Mean inhibition was 28%-35% with all doses of oxytocin, decomoton, or combined together. CONCLUSION(S): Although decomoton, an oxytocin agonist inhibited hCG-stimulated luteal cell P secretion in vitro, antocin also acted like an agonist, rather than an antagonist, in inhibiting P secretion. Published 6 December 2007 in Fertil Steril.
© 2005-2008 Gynaecology Research Today. All Rights Reserved. |
| ||||||
